Duduzane Zuma will appear at the Randburg magistrate’s court to face two counts of culpable homicide.
The charges are in connection with a 2014 crash when he collided with a taxi after losing control of his car.
Zimbabwean national Phumzile Dube was killed on the scene while another passenger Nanki Mashaba died a few weeks later.
Earlier this week, Zuma was granted bail of R100,000 after he was charged with corruption.
It’s alleged he was present when the Guptas allegedly offered former Deputy Finance Minister Mcebisi Jonas a bribe.